Three Rules for HIV Latency: Location, Location, and Location
نویسندگان
چکیده
منابع مشابه
The three most important things about origins: location, location, location
The reasons why some DNA replication origins fire earlier than others have remained elusive. New work by Gindin et al suggests that the distribution of replication origins, not their timing per se, is the major determinant of the timing of genome replication in human cells.
متن کاملLocation, location, location...
Intra-abdominal fat is an established risk factor for the metabolic syndrome. In this issue of Cell Metabolism, Tran et al. (2008) test the cell-autonomous and location-related properties of transplanted intra-abdominal and subcutaneous fat depots. While subcutaneous fat seems to confer metabolic benefits, species differences in adipose biology justify caution in interpreting the results.
متن کاملLocation, location, location
Although high levels of tumor-infiltrating lymphocytes (TILs) generally correlate with good prognosis in high-grade serous ovarian cancer (HGSC) patients, little is known about the phenotype or specificity of these cells. We have recently demonstrated that TIL expressing the intra-epithelial lymphocyte marker CD103 (official name, integrin αE, ITGAE) abundantly infiltrate HGSCs, strongly correl...
متن کاملLocation, location, location
Metastatic cell heterogeneity presents a significant obstacle to the development of targeted molecular and immunotherapeutics. Profiling of melanocyte differentiation antigens has revealed a nonstochastic, site-specific pattern of expression in metastases that was highest in brain, intermediate in soft tissues/lymph nodes, and lowest in visceral sites. Site-specific antigen heterogeneity, thus,...
متن کاملThe Latency Location-Routing Problem
This paper introduces the Latency Location-Routing Problem (LLRP) whose goal is to minimize waiting time of recipients by optimally determining both the locations of depots and the routes of vehicles. The LLRP is customer oriented by pursuing minimization of the latency instead of minimization of the length of routes. One of the main applications of this problem is the distribution of supplies ...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2013
ISSN: 1931-3128
DOI: 10.1016/j.chom.2013.05.016